What effect does glycyrrhizin from licorice root have on the adrenals?

Glycyrrhizin, a key active compound found in licorice root, primarily influences adrenal function by supporting it. This support is primarily realized through its ability to mimic the action of cortisol, which can lead to increased retention of cortisol in the body by inhibiting the enzyme 11β-HSD2. This inhibition prevents the conversion of active cortisol to its inactive form (cortisone). As a result, there can be a more prolonged action of cortisol, which can help in regulating various bodily functions that the adrenal glands are responsible for, including stress response, metabolism, and immune function.

By enhancing the bioavailability of cortisol, glycyrrhizin can create a supportive environment for adrenal function, thereby assisting the body’s response to stressors. Nevertheless, prolonged or excessive use may lead to potential suppression of cortisol production due to feedback mechanisms, but in moderate doses, it works to support adrenal function overall.

This is important to understand because it helps differentiate the effects of licorice root and its components from other potential herbal or pharmaceutical substances that may suppress adrenal function or alter hormonal levels in undesirable ways.